To Order, Call (888) 821-8808
Provider Site:  drlarson - (change)
Provider Information:
Website: drlarson
Business: Chad Larson, NMD, DC
Name: Dr. Chad Larson, DC
Phone: 888-821-8808
Home / Products / Active B-Complex

Active B-Complex

View all products by Integrative Therapeutics, Inc.
Ask a question
Size
-
+
FREE Shipping* on all orders over $89.00

Get Notified When Back In Stock


NOTIFY ME!
*By joining via text, you agree to receive recurring automated marketing messages at the cell number used to send the Join text. Consent is not a condition of any purchase. Message & data rates may apply.
Subscribe for Auto-Shipments & Get Ongoing Savings!
Auto Ship
Suggested Use: Take 1 or 2 capsules daily with meals, or as recommended by your healthcare practitioner.

Active B-Complex - A balanced, hypoallergenic B-complex featuring the active forms of vitamins B1, B2, B6, B12 and Quatrefolic® brand of (6S)-5-methyltetrahydrofolate.

Humans cannot synthesize folates. They must obtain them from dietary sources. 5-methyl-tetrahydrofolate (5-MTHF) is the predominant form of dietary folate and the only species normally found in the circulation, and thus it is the folate normally transported into peripheral tissues for use in cellular metabolism.1 Quatrefolic® is (6S)-5-methylfolate, a stable and highly-soluble form of 5-MTHF. Folic acid (FA), in contrast, is a synthetic, oxidized form of the vitamin that has been conventionally used for supplementation and food fortification. Folic acid lacks coenzyme activity and must be reduced to the metabolically active tetrahydrofolate (THF) form within the cell.

Cellular metabolism of L-methylfolate begins with conversion to unsubstituted THF in what is known as the “methylation cycle.” This conversion occurs via reaction of ingested 5-MTHF with vitamin B12- dependent methyltransferase and homocysteine to form methionine and THF, which subsequently becomes polyglutamated.2 There is some evidence, however, that the metabolic capacity of intestinal cells to reduce FA may be limited or compromised in a substantial percentage of individuals. If FA is ingested in higher doses by such individuals, unmetabolized FA may appear in the circulation.3 4 5 Although the clinical relevance of this remains unknown, the presence of unmetabolized FA may be a concern because it can enter cells, with potential of effects on folate-related cellular functions, such as synthesis of DNA and RNA.

Quatrefolic is a fourth-generation folate, stabilized as a salt of glucosamine, and has greater than 99% purity. Quatrefolic is estimated to be 100 times more soluble than the commonly used calcium salt of 5-MTHF.6 Because 5-MTHF has demonstrated bioequivalence with folic acid, supplementation with the natural folate derivative is thought to confer the beneficial effects associated with folic acid, but without the potential disadvantages of accumulation of unmetabolized folic acid or masking of vitamin B-12 deficiency.2

Quatrefolic® is a registered trademark of Gnosis S.p.A.

References

Pietrzik K, Bailey L, Shane B. Folic acid and L-5-methyltetrahydrofolate: comparison of clinical pharmacokinetics and pharmacodynamics. Clin Pharmacokinet. 2010 Aug;49(8):535-48. Pentieva K, McNulty H, Reichert R, et al. The short-term bioavailabilities of [6S]-5-methyltetrahydrofolate and folic acid are equivalent in men. J Nutr. 2004 Mar;134(3):580-5. Perry J, Chanarin I. Intestinal absorption of reduced folate compounds in man. Br J Haematol. 1970;18: 329-39. Kelly P, McPartlin J, Goggin M, Weir DG, Scott JM. Unmetabolized folic acid in serum: acute studies in subjects consuming fortified food and supplements. Am J Clin Nutr. 1997;65:1790-5. Fohr IP, Prinz-Langenohl R, Brönstrup A, et al. 5, 10-Methylenetetrahydrofolate reductase genotype determines the plasma homocysteine-lowering effect of supplementation with 5-methyltetrahydrofolate or folic acid in healthy young women. Am J Clin Nutr. 2002;75:275-82. Gnosis USA, Inc. Quatrefolic Solubility Statement. Data on file.

Supplement Facts:
Suggested Use: Take 1 or 2 capsules daily with meals, or as recommended by your healthcare practitioner.
1 Veg Capsule
IngredientsAMT%DV
Thiamin (as thiamin HCl) (vitamin B1)50 mg3,334%
Riboflavin (as riboflavin and riboflavin-5'-phosphate)50 mg2,942%
Niacin (as inositol hexaniacinate)100 mg500%
Vitamin B6 (as pyridoxine HCl and pyridoxal-5'-phosphate)50 mg2,500%
L-Methyltetrahydrofolate (as Quatrefolic® brand (6S)-5-Methyltetrahydrofolate, glucosamine salt)800 mcg200%
Vitamin B12 (as methylcobalamin)1 mg16,666%
Biotin300 mcg100%
Pantothenic Acid (as calcium D-pantothenate)100 mg1,000%
Choline Bitartrate250 mg-
Inositol250 mg-
Other Ingredients: vegetable capsule (modified cellulose), cellulose, calcium laurate, and silicon dioxide.
(-) There is no %DV or the manufactuer has not provided this data.
Questions About This Product?
Phone us at 888-821-8808
Online Health Care Connection:
Do you have questions about this product or would like to connect with your Health Care Provider? We are proud to offer Virtual Visit.
Get Healthy With Virtual Visit!
Your health care professional will be able to provide you with tailored product recommendations, advice, and exclusive promotions to help save you money on professionally formulated, high potency natural health products not found in stores.
Don't have an account or would like to learn more about Virtual Visit technology?
Sign up here!
Related Products:

Shop All Products

Office Location and Hours:
Chad Larson, NMD, DC
437 S. Highway 101 209
Solana Beach, CA, 92075, 
    Contact Us
Office Hours
Mon: Closed
Tue:9AM - 5PM
Wed: Closed
Thu:11AM - 3PM
Fri:9AM - 5PM
Sat: Closed
Sun:Closed
Browse Categories: