Two studies report that administering high doses of niacin (vitamin B3), a drug used for the prevention of cardiovascular disease, has mixed results for heart health. Published in The New England Journal of Medicine, the studies involved giving at least 1500 mg of niacin to individuals who had established cardiovascular or vascular disease. While niacin improved cholesterol levels and reduced triglyceride levels, it did not seem to reduce risk of heart disease, stroke, or death, and was associated with serious side effects. Critics of these studies point out that the results may be skewed because study participants were already at high risk for health problems, and ask whether niacin might still be very useful for patients with different health profiles.
Source: The New York Times