Suggested Use: As a dietary supplement,
adults take 1 lozenge daily, or as directed by
your healthcare professional. Allow lozenge to
dissolve in mouth and then swallow
Vitamin B-12 -
Hydroxycobalamin is a precursor form of B12 which is essential for the metabolism of macronutrients, methionine and DNA synthesis. It is converted to both methylcobalamin and adenosylcobalamin to support methylation, nerve and mitochondrial health.†
Vitamin B12 is essential for normal energy metabolism of carbohydrates, fat and protein.† As a cofactor for
methylmalonyl-CoA mutase enzymes, vitamin B12 helps convert odd chain fatty acids and branched chain
amino acids into succinyl-CoA, a common citric acid cycle intermediate. Vitamin B12 is also required for
nucleic acid (DNA) synthesis, methionine synthesis from cysteine, and normal myelin synthesis in the nervous
system. Along with vitamin B6 and folic acid, adequate levels of vitamin B12 are required to maintain normal
plasma homocysteine levels.†
There are two distinct mechanisms for intestinal vitamin B12 absorption; receptor-mediated absorption and
passive diffusion. In the first, vitamin B12 attaches to a salivary “R-binder” protein which transports it into the
small intestine, where vitamin B12 is released. The vitamin then binds to “Intrinsic Factor” (IF), a glycoprotein
normally produced by the gastric parietal cells. This vitamin B12-IF complex is carried down to the ileum, where
it binds to mucosal receptors. Finally, the complex is absorbed and bound to serum vitamin B12-binding
proteins. The second absorption mechanism, passive diffusion, does not require any carriers, such as B-binder
or IF. The elderly and strict vegetarians are often at risk for vitamin B12 deficiency, either due to low dietary
intake or impaired absorption.
The receptor-mediated absorption pathway is subject to numerous genetic and pathologic defects which can
severely impair normal vitamin B12 absorption. .
Hydroxycobalamin is a precursor form of vitamin B12 converted in the body to both methylcobalamin and
adenosylcobalamin. It is similar to cyanocobalamin without the cyanide moiety. This form of unmethylated
B12 promotes nerve and mitochondrial health.†
Supplement Facts:Suggested Use: As a dietary supplement, adults take 1 lozenge daily, or as directed by your healthcare professional. Allow lozenge to dissolve in mouth and then swallow
Ingredients | AMT | %DV |
Vitamin B12 (as hydroxycobalamin) | 2,500 mcg | 104,166% |
Other Ingredients: Xylitol, mannitol, natural black
cherry and natural vanilla flavor,
carboxymethylcellulose, and ascorbyl palmitate.
(-) There is no %DV or the manufactuer has not provided this data.
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