Suggested Use: 1 capsule, 2 times daily, with meals.
This formula requires refrigeration after opening.
Homocysteine Factors™ -
Helps maintain normal homocysteine levels and cardiovascular health. A highly bioavailable combination of nutrients integral to supporting normal homocysteine levels and cardiovascular health.
What Is It?
Homocysteine Factors provides activated vitamin B6
(pyridoxal 5-phosphate), vitamin B12, folate (Metafolin®,
L-5-MTHF) and betaine, a highly bioavailable combination
of nutrients integral to supporting healthy homocysteine
levels and cardiovascular health.*
Uses For Homocysteine Factors
Cardiovascular Health: Clinical studies show that folate,
vitamin B12, and vitamin B6 are vital in the metabolism
of homocysteine. Vitamin B12 and folate are required
by the enzyme that converts homocysteine back to
methionine. Folate is provided in this formula
as Metafolin®, the naturally occurring universally
metabolized form of folate. Metafolin® is chemically
identical to the active folate metabolite, 5-methyltetrahydrofolate
(L-5-MTHF). L-5-MTHF is the predominant,
naturally occurring form of folate in food. Through
bypassing several enzymatic activation steps, it is
directly usable by the body and provides all of the
benefits of folic acid regardless of functional or genetic
variations. Vitamin B6 is required in each of the two
enzymatic reactions that convert homocysteine to
cysteine. One of the major roles of betaine, also known as
trimethylglycine, is in promoting healthy homocysteine
metabolism. In a recent study, a betaine-rich diet or
betaine supplementation supported healthy homocysteine
metabolism in men and women. It is believed that betaine
may be especially supportive when vitamin B12, folic acid
and vitamin B6 are not sufficient to maintain healthy
As part of a well-balanced diet that is low in saturated fat
and cholesterol, folic acid, vitamin B6, and vitamin B12 may
reduce the risk of vascular disease.†
†The FDA evaluated the above claim and found that while
it is known that diets low in saturated fat and cholesterol
reduce the risk of heart disease and other vascular
diseases, the evidence in support of the above claim is
What Is The Source?
Vitamin B12 is derived from microbiological fermentation.
Vitamin B6 and folic acid (Metafolin®, L-5-
MTHF) are synthetically produced. Betaine is originally
derived from sugar beet molasses and undergoes
an extensive purification process. Vitamin C (ascorbyl
palmitate) is derived from corn dextrose fermentation and
hypoallergenic plant fiber is derived from pine cellulose.
Metafolin® is a registered Trademark of Merck KGaA,
Pure Encapsulations recommends 2 capsules per day,
in divided doses, with meals. This formula requires
refrigeration after opening
Are There Any Potential Side Effects Or
At this time, there are no known side effects or precautions.
If pregnant or lactating, consult your physician before
taking this product.
Are There Any Potential Drug Interactions?
Folic acid-containing supplements may interfere with
methotrexate therapy in people with cancer.